×
Entrez Id: 5071
Gene Symbol: PRKN
PRKN
Parkinson Disease
0.600
Therapeutic
RGD
Thymoquinone exerts neuroprotective effect in animal model of Parkinson's disease.
28526446 2017
×
Entrez Id: 10133
Gene Symbol: OPTN
OPTN
Parkinson Disease
0.260
Biomarker
RGD
To test our hypothesis, we characterized midbrain OPTN expression in normal rats and in a rat rotenone PD model.
27473339 2016
×
Entrez Id: 3297
Gene Symbol: HSF1
HSF1
Parkinson Disease
0.210
Therapeutic
RGD
Modulatory effects of sodium salicylate on the factors affecting protein aggregation during rotenone induced Parkinson's disease pathology.
24852355 2014
×
Entrez Id: 25
Gene Symbol: ABL1
ABL1
Parkinson Disease
0.220
Biomarker
RGD
However, only c-Abl protein levels were found to be upregulated in PD brains.
24412932 2014
×
Entrez Id: 8200
Gene Symbol: GDF5
GDF5
Parkinson Disease
0.230
Biomarker
RGD
It found that endogenous GDF5 , GDNF and their receptors are differentially expressed in two 6-hydroxydopamine lesion models of PD .
24373993 2014
×
Entrez Id: 3297
Gene Symbol: HSF1
HSF1
Parkinson Disease
0.210
Biomarker
RGD
Long-term heat shock proteins (HSPs) induction by carbenoxolone improves hallmark features of Parkinson's disease in a rotenone-based model.
24296154 2014
×
Entrez Id: 11315
Gene Symbol: PARK7
PARK7
Parkinson Disease
0.600
Biomarker
RGD
Pathogenic autosomal recessive mutations in the DJ-1 (Park7 ) or the PTEN-induced putative kinase 1 (Pink1 or PARK6) genes are associated with familial Parkinson's disease (PD ).
24157858 2013
×
Entrez Id: 65018
Gene Symbol: PINK1
PINK1
Parkinson Disease
0.600
Biomarker
RGD
These distinctive changes in the expression of dopamine presynaptic markers and receptors in the striatum may reflect different compensatory regulation of dopamine system in DJ-1 versus Pink1 knockout rat models of familial PD .
24157858 2013
×
Entrez Id: 3329
Gene Symbol: HSPD1
HSPD1
Parkinson Disease
0.210
Biomarker
RGD
Taken together, our results suggested that Hsp60 could be released extracellularly to activate microglia in Parkinson's disease model.
23943523 2013
×
Entrez Id: 9638
Gene Symbol: FEZ1
FEZ1
Parkinson Disease
0.200
Biomarker
RGD
Immunohistochemistry was performed to identify the cellular localization of FEZ1 in sham-lesioned and PD rats.
23888906 2014
×
Entrez Id: 1627
Gene Symbol: DBN1
DBN1
Parkinson Disease
0.200
Therapeutic
RGD
Immunoelectron microscopic examinations confirmed that drebrin -immunoreactive spines became enlarged in the dopamine-denervated striatum of the levodopa-induced dyskinesia model, but not in the Parkinson's disease model.
23241013 2013
×
Entrez Id: 3553
Gene Symbol: IL1B
IL1B
Parkinson Disease
0.300
Biomarker
RGD
Anti-inflammatory properties rather than anti-oxidant capability is the major mechanism of neuroprotection by sodium salicylate in a chronic rotenone model of Parkinson's disease.
23159314 2013
×
Entrez Id: 2932
Gene Symbol: GSK3B
GSK3B
Parkinson Disease
0.300
Therapeutic
RGD
Neuroprotection by urate on 6-OHDA-lesioned rat model of Parkinson's disease: linking to Akt/GSK3β signaling pathway.
23094836 2012
×
Entrez Id: 1812
Gene Symbol: DRD1
DRD1
Parkinson Disease
0.570
Therapeutic
RGD
PSD-95 expression controls L-DOPA dyskinesia through dopamine D1 receptor trafficking.
23041629 2012
×
Entrez Id: 3308
Gene Symbol: HSPA4
HSPA4
Parkinson Disease
0.300
Biomarker
RGD
Mildronate as a regulator of protein expression in a rat model of Parkinson's disease.
22186119 2011
×
Entrez Id: 57165
Gene Symbol: GJC2
GJC2
Parkinson Disease
0.200
Therapeutic
RGD
Nigrostriatal proteomics of cypermethrin-induced dopaminergic neurodegeneration: microglial activation-dependent and -independent regulations.
21561882 2011
×
Entrez Id: 4537
Gene Symbol: ND3
ND3
Parkinson Disease
0.210
Biomarker
RGD
Protective effect of lycopene on oxidative stress and cognitive decline in rotenone induced model of Parkinson's disease.
21484267 2011
×
Entrez Id: 7054
Gene Symbol: TH
TH
Parkinson Disease
0.600
Biomarker
RGD
Protective effect of resveratrol derived from Polygonum cuspidatum and its liposomal form on nigral cells in parkinsonian rats.
21376343 2011
×
Entrez Id: 6571
Gene Symbol: SLC18A2
SLC18A2
Parkinson Disease
0.600
Biomarker
RGD
Protective effect of Zhen-Wu-Tang (ZWT) through keeping DA stable and VMAT 2/DAT mRNA in balance in rats with striatal lesions induced by MPTP.
21291984 2011
×
Entrez Id: 131
Gene Symbol: ADH7
ADH7
Parkinson Disease
0.220
Biomarker
MGD
Modeling Parkinson's disease genetics: altered function of the dopamine system in Adh4 knockout mice.
21075145 2011
×
Entrez Id: 10094
Gene Symbol: ARPC3
ARPC3
Parkinson Disease
0.200
Therapeutic
RGD
Antiparkinsonian trophic action of glial cell line-derived neurotrophic factor and transforming growth factor β1 is enhanced after co-infusion in rats.
20713051 2010
×
Entrez Id: 3350
Gene Symbol: HTR1A
HTR1A
Parkinson Disease
0.230
Biomarker
RGD
Our study indicates that buspirone improves catalepsy in a 6-OHDA-induced animal model of Parkinson's disease through activation of nigral 5-HT(1A ) receptors.
20508280 2010
×
Entrez Id: 5309
Gene Symbol: PITX3
PITX3
Parkinson Disease
0.300
Biomarker
MGD
Microphthalmia, parkinsonism, and enhanced nociception in Pitx3 ( 416insG ) mice.
20033184 2010
×
Entrez Id: 3480
Gene Symbol: IGF1R
IGF1R
Parkinson Disease
0.510
Biomarker
RGD
Ginsenoside Rg1 protects dopaminergic neurons in a rat model of Parkinson's disease through the IGF-I receptor signalling pathway.
19703168 2009
×
Entrez Id: 5764
Gene Symbol: PTN
PTN
Parkinson Disease
0.210
Therapeutic
RGD
Heparin-binding determinants of GDNF reduce its tissue distribution but are beneficial for the protection of nigral dopaminergic neurons.
19615368 2009